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Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
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- SUGAYA Kiminobu
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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- MATSUDA Ikuko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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- KUBOTA Kazuhiko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
Bibliographic Information
- Other Title
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- Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepines antagonist, Ro 15-1788
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Description
Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered 1ntraperitonea Ily. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a dose of 200 mg/kg. Benzodiazepines and Ro 15-1788 revealed a considerably strong hypothermic effect, but they still prevented the hypothermic effect of cholecystokinin. The precise mechanism of the antagonism between cholecystokinin and benzodiazepines remains unclear at present.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 39 (2), 277-280, 1985
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679264995968
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- NII Article ID
- 130000834773
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- COI
- 1:CAS:528:DyaL2MXlslajs7Y%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 2868143
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed