Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepines antagonist, Ro 15-1788
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- SUGAYA Kiminobu
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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- MATSUDA Ikuko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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- KUBOTA Kazuhiko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
書誌事項
- タイトル別名
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- Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
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説明
Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered 1ntraperitonea Ily. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a dose of 200 mg/kg. Benzodiazepines and Ro 15-1788 revealed a considerably strong hypothermic effect, but they still prevented the hypothermic effect of cholecystokinin. The precise mechanism of the antagonism between cholecystokinin and benzodiazepines remains unclear at present.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 39 (2), 277-280, 1985
公益社団法人 日本薬理学会
