Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.

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  • SUGAYA Kiminobu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
  • MATSUDA Ikuko
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
  • KUBOTA Kazuhiko
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo

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  • Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepines antagonist, Ro 15-1788

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Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered 1ntraperitonea Ily. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a dose of 200 mg/kg. Benzodiazepines and Ro 15-1788 revealed a considerably strong hypothermic effect, but they still prevented the hypothermic effect of cholecystokinin. The precise mechanism of the antagonism between cholecystokinin and benzodiazepines remains unclear at present.

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