Effects of an angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.

TAKADA Toyokazu, YAMAMOTO Kenjiro, FUJIOKA Shoji, TAMAKI Toshiaki, FUKUI Kiyoshi, ABE Youichi

doi:10.1254/jjp.38.227

Effects of an angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.

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TAKADA Toyokazu

Department of Pharmacology, Osaka City University Medical School
YAMAMOTO Kenjiro

Department of Pharmacology, Osaka City University Medical School
FUJIOKA Shoji

Department of Pharmacology, Kagawa Medical School
TAMAKI Toshiaki

Department of Pharmacology, Kagawa Medical School
FUKUI Kiyoshi

Department of Pharmacology, Kagawa Medical School
ABE Youichi

Department of Pharmacology, Kagawa Medical School

説明

The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.