Concerning substances in whey that inhibit diarrhea and consequent trophopathy developed with lactose and galactose

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  • 田村 俊吉
    Department of Pharmacology, Tokyo Dental College, and Tamura Research Laboratory for Experimental Medicine
  • 堤 璋二
    Department of Pharmacology, Tokyo Dental College, and Tamura Research Laboratory for Experimental Medicine
  • 伊藤 博夫
    Department of Pharmacology, Tokyo Dental College, and Tamura Research Laboratory for Experimental Medicine

書誌事項

タイトル別名
  • STUDIES ON THE PROMOTING FACTORS OF GALACTOSE AND LACTOSE METABOLISM IN THE WHEY
  • II. THE EFFECT OF THE PROMOTING FACTORS ON THE GALACTOSE AND LACTOSE METABOLISM UPON THE ACTIVITY OF D-GLUCOSE-6-PHOSPHATE: NADP OXIDOREDUCTASE AND THE ELECTROLYTES INCLUDED IN THE EYE-BALL OF THE CATARACT RAT

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説明

Mitchell and Dodge (1) have already reported that cataracts broke out in rats fed on a diet containing hyper-lactose, and thus lactose and galactose would be recognized as the factors inducing the cataracts. On the other hand, there were some investigations that cataracts in rats were inhibited by whey. Takuma and Takayama (2) confirmed that a cataract caused by purified lactose was prevented by the addition of whey. Moreover, Ogihara (3) extracted an agent preventing cataract in the whey. Lerman (4) and Schwarz and Golberg (5) noted that the concentration of galactose-l-phosphate(Gal-l-P) in the lenses of cataract-rats caused by an excess of galactose was approximately ten times as thick as is in the normal rat's lenses. Since the metabolism of the lens is dependent upon glucose as its main source of energy, an accumulation of Gal-l-P in the lens may be a promoting factor in the development of the experimental galactose cataract. It has been shown that an excess of Gal-l-P induces a depression of the hexose monophosphate shunt in the lenses (6, 7). This finding supported other reports (8-10) of a depressed activity of D-glucose-6-phosphate: NADP oxidoreductase (1.1.1.49) in the lenses, measured under the same conditions. Korc investigated that the activity of D-glucose-6-phosphate: NADP oxidoreductase of erythrocyte and liver was more accelerated in the rats fed on the galactose diet than in normal rats.<BR> As shown in the investigations mentioned above, these disturbances of galactose metabolism may be the cause of such cataracts.<BR> There are many reports concerning changes of electrolyte concentration in the rat's lenses caused by a diet containing an excess of lactose or galactose. Salit, Swan and Paul (11) and Hill and Heggeness (12) observed that there was a high concentration of sodium and calcium and a low concentration of potassium.<BR> In the present investigations, the authors tried to ascertain the activity of D-glucose-6-phosphate: NADP oxidoreductase (1.1.1.49) in the eye-ball and erythrocyte and changes of electrolytes in the eye-balls in rats fed on a diet containing an excess of lactose and galactose. Moreover, the authors tried to show the effects of the promoting factors of lactose and galactose metabolism in the whey upon this enzyme system and the -changes of electrolytes.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 19 (1), 163-167, 1969

    公益社団法人 日本薬理学会

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