Studies on combination dosing. III. Aspirin and ethenzamide.

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  • KAWANO Osamu
    Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
  • SAWABE Takashi
    Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
  • MISAKI Noriyuki
    Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
  • FUKAWA Kazunaga
    Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

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  • Studies of combination dosing-3-Aspirin and ethenzamide
  • Studies of combination dosing 3 Aspirin

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Abstract

In our studies with drug combinations, we searched for mixtures which would enhance the effectiveness of the related active substances. Ethenzamide was found to possess a specific suppressive effect on the gastric damage induced by aspirin. Such effect could not be demonstrated in analgesic agents such as salicylamide, bucetin, acetaminophen and phenacetin. The combination of aspirin with ethenzamide had a potentiating effect on analgesic activity and reduced motor incoordination and loss of righting reflex. We calculated the safety margins of various ratios of combinations and concluded that the best was aspirin and ethenzamide at a ratio of 2:3.

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