ACTION OF RESERPINE ON THE LETHAL EFFECT OF CYTOTOXIC ALKYLATING AGENTS

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Abstract

Since 1953 we have studied the specific toxicogenic mechanism of various nitrogen mustard derivatives (1-10). As described by Philips (11), Goodman and Gilman (12) and Yamamoto et al. (4, 6), the toxicity of nitrogen mustards can be broadly classified into acute and delayed cytotoxic actions, both of which are extremely specific. Because of the toxicity of these drugs there is consequently a clinical restriction in the dosage. However, as these nitrogen mustard derivatives show a significant morphological effect on experimental cancer, extensive basic and clinical studies are still being continued on these compounds to search more excellent cancer chemotherapy. In the present study methyl-bis (β-chloroethyl) amine N-oxide hydrochloride (nitromin) was selected and investigations were directed to reduce its toxicity. Data obtained demonstrated that the pretreatment with reserpine inhibited the lethality of nitromin and thus further studies were made on its inhibition mechanism with relation to biogenic amines.

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