A PHOTOELECTRIC METHOD FOR ESTIMATING INFLAMMATORY INTENSITY IN MICE AND ITS APPLICATION TO THE ANTI-INFLAMMATORY EVALUATION OF GLUCURONIC ACID DERIVATIVES

DOI Web Site PubMed
  • 佐藤 徳光
    Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • 氷室 育三
    School of Pharmaceutical Sciences, Kitazato University
  • 塩屋 明利
    Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

この論文をさがす

抄録

As is well known, intravenously administered dye extravasates at the site of inflammation (1-4). This phenomenon has been used as one of the bases for the bioassay of experimentally induced inflammation (5-10). However, estimation of the extravasated dye either directly or by comparison to standard color chart, was not always satisfactory because of being influenced by subjective bias. Subsequently, Sachs and Lummis (11) recommended the spectrophotemetric measurement of the dye extracted from the inflammed tissue. In this paper, the authors propose a convenient method for the quantitative estimation of extravasated dye at the site of inflammation in mice using a photoelectric technique. The technique was utilized to demonstrate the anti-inflammatory activity of cortisone, salicylates, aminopyrine, tripelennamine, and glucuronic acid derivatives.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 17 (4), 557-571, 1967

    公益社団法人 日本薬理学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ