EFFECT OF ADMINISTRATION OF 3-AMINOTRIAZOLE ON THE ACTIVITY OF MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEMS OF RAT LIVER
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- 加藤 隆一
- Department of Pharmacology and Department of Toxicology, National Institute of Hygienic Sciences
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The administration of phenobarbital and other drugs increases the activities of drug-metabolizing enzymes, NADPH dehydrogenase and NADPH-cytochrome c reductase of liver microsomes (1-4). Moreover, it was reported that the administration of phenobarbital also increased the amount of P-450 in liver microsomes (4-6), which is a haemoprotein pigment of microsomes and probably have an important role for the oxidation of drugs (4-10). Recently, Granick and Urata demonstrated that the administration of many drugs, including phenobarbital, markedly increased the activities of δ-amino levulonic acid synthetase and synthesis of porphyrine (11, 12). These results suggested that the increase in the activities of drug-metabolizing enzymes after the administration of phenobarbital may be due to the results of the increasing amount of P-450 through an increased synthesis of porphyrine. On the other hand, administration of 3-amino-1, 2, 4-triazole markedly depressed the activity of liver and kidney catalase (13, 14). The action of 3-aminotriazole on the activity of liver catalase is not yet clear, and some results indicate that 3-aminotriazole may inhibit δ-adminolevulonic acid dehydrase and other enzymes for the synthesis of porphyrine in liver (15, 16). Thus, the purpose of the present communication is to investigate the action of 3-aminotriazole on the induction of drug-metabolizing enzyme systems and the increase in the amount of P-450 content of liver microsomes by the administration of phenobarbital.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 17 (1), 56-63, 1967
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679265679104
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- NII論文ID
- 130000836573
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaF2sXhtFCnsrw%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 8509244
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- PubMed
- 5299975
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
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- 使用不可