Effect of fentanyl,a narcotic analgesic,on two components of jaw opening reflex

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  • NISHIJIMA Yoshiaki
    Medical Laboratory for Pharmacology, Central Research Laboratories, Sankyo Co., Ltd.
  • SAKAI Yutaka
    Medical Laboratory for Pharmacology, Central Research Laboratories, Sankyo Co., Ltd.

書誌事項

タイトル別名
  • EFFECT OF FENTANYL, A NARCOTIC ANALGESIC, ON TWO COMPONENTS OF THE JAW OPENING REFLEX
  • Effect of fentanyl a narcotic analgesic

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説明

An action of fentanyl, a short-acting narcotic, on the reflex discharge in the digastric nerve induced by the inferior alveolar nerve stimulation was investigated in α-chloralose anesthetized cats. In the ipsilateral digastric reflex discharge, there were an early phase induced by stimulus exciting Aα fibers and a late phase appearing when Aδ fibers were also stimulated. Following dorso-lateral cordotomy at the obex level, an isolation of the spinal trigeminal nucleus caudalis, a total area in the digastric reflex discharge decreased, while its first peak amplitude was little affected, indicating a disappearance of the late phase and a preservation of the early phase. Fentanyl depressed both the total discharge area and the first peak amplitude. After dorsolateral cordotomy, the depression of the area decreased considerably, whereas that of the amplitude decreased slightly. Results indicate that fentanyl depressed both the early phase which is activated by the Aα fiber stimulation, not via the subnucleus caudalis and the late phase which is activated by the Aδ fiber stimulation via the subnucleus caudalis or its surroundings. The latter action would be related to the analgesic action of fentanyl.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 25 (3), 335-344, 1975

    公益社団法人 日本薬理学会

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