MEASUREMENT OF ARTHRITIC PAIN AND EFFECTS OF ANALGESICS IN THE ADJUVANT-TREATED RAT
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- HIROSE Katsumi
- Shionogi Research Laboratory, Shionogi & Co., Ltd.
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- JYOYAMA Hirokuni
- Shionogi Research Laboratory, Shionogi & Co., Ltd.
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Adjuvant-induced arthritis in rat is widely used in laboratories for evaluating of the antirheumatic activity of drugs, since the pathophysiological syndromes in arthritic rats are analogous to those in rheumatoid arthritis patients in many respects, and since the method is simple and gives satisfactory reproducibility of results (1-3). Many reports have dealt with the anti-inflammatory activity of drugs on adjuvant-induced arthritis, but very little study has been done on the analgesic activity of a single dose of drug in arthritic rat. The great reduction of the reaction threshold to a mechanical stimulus in the arthritic foot of the rat prompted us to utilize this hyperesthesia for testing analgesic activity of drug, especially non-narcotic analgesics.<BR> In the present report a simple method for the determination of the pain threshold in arthritic foot is described and the effects of several non-narcotic analgesics, hydrocortisone and morphine are studied.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 21 (6), 717-720, 1971
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679265805696
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- NII論文ID
- 130000837730
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaE38XktVSjurk%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 8509671
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- PubMed
- 5316860
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可