EFFECT OF HISTAMINE ON OXYGEN CONSUMPTION IN GUINEA PIG TAENIA COLI

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  • SAITO Yukio
    Medical Laboratory for Pharmacology, Central Research Laboratories, Sankyo Co. Ltd.
  • SAKAI Yutaka
    Medical Laboratory for Pharmacology, Central Research Laboratories, Sankyo Co. Ltd.
  • IKEDA Miyoshi
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
  • URAKAWA Norimoto
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo

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抄録

In 1953, Bülbring noted that the smooth muscle of teania coli from guinea pig showed an increase in oxygen consumption associated with tension development when stimulated by a drug such as acetylcholine, histamine or eserine (1). Recently Urakawa and his coworkers found that high concentration of potassium in Tyrode solution induced an increase in oxygen consumption accompanied by a rise of muscle tension (2), and they considered that Ca ions which entered the muscle cells through the membrane depolarized by high K might play an essential role in increasing oxygen consumption independently of an increase in muscle tension (3).<BR> The present experiments were undertaken to investigate effects of histamine and its antagonist on oxygen consumption, muscle tension and electrical activity in taenia coli, and the relationship between the resulting increase in oxygen consumption and Ca movement was discussed.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 21 (5), 605-611, 1971

    公益社団法人 日本薬理学会

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