Immunological properties and examination of some species difference

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  • OHISHI Iwao
    Biochemical Pharmacology Laboratory, Research Laboratories, Chugai Pharmaceutical Co.. Ltd.
  • SHIOYA Akitoshi
    Biochemical Pharmacology Laboratory, Research Laboratories, Chugai Pharmaceutical Co.. Ltd.

書誌事項

タイトル別名
  • RABBIT LIVER β-GLUCURONIDASE
  • II. IMMUNOLOGICAL PROPERTIES AND EXAMINATION OF SOME SPECIES DIFFERENCE

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抄録

In the accompanying paper (1), we have reported the purification procedure of rabbit liver β-glucuronidase. The purified enzyme was found to be highly homogeneous according to gel filtration, disc electrophoresis and immunological double diffusion analyses.<BR> It was the purpose of this study to investigate the possibility of differentiating immunologically the liver enzyme from those present in other organs of rabbit. We considered that, if such differentiation was possible, the origin of the β-glucuronidase activity in serum, which increased under various experimental (administration of glucose, epinephrine, alloxan (2, 3), and certain hexoses (4)) and clinicaly diabetic conditions (5-7), would readily be determined.<BR> This immunological study was extended to include some species difference in liver β-glucuronidase and the nature (enzyme activity) of the antigen-antibody complex.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 21 (4), 551-556, 1971

    公益社団法人 日本薬理学会

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