Norepinephrine-synthesizing enzymes in brain, adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats.

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  • NAGATSU Toshiharu
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuda, Tokyo Omstotite of Technology
  • KATO Takeshi
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuda, Tokyo Omstotite of Technology
  • NUMATA(SUDO) Yukiko
    Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuda, Tokyo Omstotite of Technology
  • IKUTA Keiko
    Departments of Biochemistry and Anatomy, School of Dentistry, Aichi-Gakuin University
  • SANO Masao
    Departments of Biochemistry and Anatomy, School of Dentistry, Aichi-Gakuin University
  • NAGATSU Ikuko
    Department of Anatomy: School of Medicine, Fujita-Gakuen University
  • UMEZAWA Hamao
    Institute of Microbial Chemistry
  • MATSUZAKI Meiki
    Institute of Microbial Chemistry
  • TAKEUCHI Tomio
    Institute of Microbial Chemistry

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  • Norepinephrine-syntesizing enzymes in brain,adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats
  • Norepinephrine syntesizing enzymes in b

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Dopamine-β-hydroxylase (DBH) activity in scrum, DBH and tyrosine hydroxylase (TH) activities in mesenteric vessels, and DBH and TH activities in locus coeruleus and hypothalamus of brain did not differ significantly between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKR) at 16 weeks of age when hypertension of SHR was fixed. In contrast, DBH and TH activities in vas deferens and adrenal glands were significantly higher in SHR than in WKR. These changes in SHR at 16 weeks of age after establishment of hypertension are directly opposite those reported previously in SHR at 3 weeks of age before the onset of hypertension.

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