Contractile responses of isolated dog mesenteric arteries to angiotensin I, II and III.

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  • TODA Noboru
    Department of Pharmacology, Shiga University of Medical Sciences
  • HAYASHI Shigehiro
    Department of Pharmacology, Shiga University of Medical Sciences
  • MIYAZAKI Mizuo
    Department of Pharmacology, Shiga University of Medical Sciences

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  • Contractile Responses of Isolated Dog Mesenteric Arteries to Angioensin 1,2 and 3
  • Contractile Responses of Isolated Dog M

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Abstract

The addition of angiotensin (Ang-) I, II and III caused a dose-dependent contraction of helically cut strips of dog mesenteric arteries. Tachyphylaxis developed following repeated additions of angiotensins. Average median effective concentrations of Ang-I, II and III were 3.7, 0.8 and 2.5×10-8 M, respectively. Contractile responses to the angiotensins were attenuated to a similar extent by Ang-II antagonists, Sarl Ileu8 Ang-II and Sar1 Ala8 Ang-II, but were unaffected by phentolamine, methysergide and diphenhydramine. The response to Ang-I was significantly reduced by treatment with bradykinin-potentiator B, while the response to Ang-II was not influenced. It may be concluded that Ang-I, II and III produce contractions possibly by activation of same Ang-II receptors and that contractions induced by Ang-I are associated, to some extent, with a conversion to Ang-II in the arterial wall.

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