THE EFFECT OF 2: 2-DIPHENYL-4-N-HEXAMETHYLENIMINO-BUTYRAM IDE METHIODIDE ON EXPERIMENTAL CHRONIC ULCER IN GLANDULAR STOMACH OF RATS
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- HISAMATSU Takashi
- Research Laboratories, Meiji Seika Kaisha, Ltd.
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- NAKAZAWA Tadashi
- Research Laboratories, Meiji Seika Kaisha, Ltd.
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- KOEDA Takemi
- Research Laboratories, Meiji Seika Kaisha, Ltd.
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抄録
2: 2-Diphenyl-4-N-hexamethylenimino-butyramide methiodide (R-661) is one of the series of substituted diphenylpropyl-amines synthesized by Janssen et al. and is a typical quaternary atropine-like substance (1-9). It has anticholinergic activity, namely, parasympatholytic activity.<BR> Additionally, Janssen et al. reported that this compound showed the excellent gastrointestinal absorption and inhibited the formation of experimental gastric ulcer in rats (9). In the present experiments, an attempt was made histo-pharmacologically to evaluate the curative effect of R-661 on experimental ulcers in glandular stomachs of rats.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 21 (2), 139-154, 1971
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679266158976
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- NII論文ID
- 130000837551
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaE3MXkslCmtb4%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 8509595
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- PubMed
- 5314275
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可