A pharmacological study of 6-hydroxy 4a,10-trimethylene-1,2,3,4,4a,9,10,10a-octahydrophenanthridine
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- FUJIMURA HAJIME
- Institute for Chemical Research, Kyoto University
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- SUGIMOTO NORIO
- Osaka Research Laboratory, Tanabe Seiyaku Co.
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- HAYASHI GORO
- Osaka Research Laboratory, Tanabe Seiyaku Co.
書誌事項
- タイトル別名
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- A PHARMACOLOGICAL STUDY OF 6-HYDROXY-4a, 10-TRIMETHYLENE-1, 2, 3, 4, 4a, 9, 10, l0a-OCTAHYDROPHENANTHRIDINE
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説明
The structure-activity relationship of various chemical compounds, which resembled to morphine in their structures and were synthesized by Sugimoto et al. (1), has been reported. Among those compounds a racemic 6-hydroxy-4a, 10-trimethylene-1, 2, 3, 4, 4a, 9, 10, 10a-octahydrophenanthridine hydrochloride (DH-7), which have a nitrogen atom at 9-position of the morphinan ring, showed almost the same strong analgesic activities as morphine hydrochloride in a series of screening test.<BR> Further studies of the analgesic activity of DH-7 and the comparative pharmacological studies of the drug with morphine hydrochloride and levorphanol tartrate are described in this report. DH-7 has a chemical structure, shown in the following structural formula.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 11 (2), 101-113, 1962
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679266639232
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- NII論文ID
- 130000836001
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- NII書誌ID
- AA00691188
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 9245564
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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