A pharmacological study of 6-hydroxy 4a,10-trimethylene-1,2,3,4,4a,9,10,10a-octahydrophenanthridine

FUJIMURA HAJIME, SUGIMOTO NORIO, HAYASHI GORO

doi:10.1254/jjp.11.101

A pharmacological study of 6-hydroxy 4a,10-trimethylene-1,2,3,4,4a,9,10,10a-octahydrophenanthridine

DOI Web Site Web Site Web Site 参考文献4件オープンアクセス

FUJIMURA HAJIME

Institute for Chemical Research, Kyoto University
SUGIMOTO NORIO

Osaka Research Laboratory, Tanabe Seiyaku Co.
HAYASHI GORO

Osaka Research Laboratory, Tanabe Seiyaku Co.

書誌事項

タイトル別名

A PHARMACOLOGICAL STUDY OF 6-HYDROXY-4a, 10-TRIMETHYLENE-1, 2, 3, 4, 4a, 9, 10, l0a-OCTAHYDROPHENANTHRIDINE

この論文をさがす

説明

The structure-activity relationship of various chemical compounds, which resembled to morphine in their structures and were synthesized by Sugimoto et al. (1), has been reported. Among those compounds a racemic 6-hydroxy-4a, 10-trimethylene-1, 2, 3, 4, 4a, 9, 10, 10a-octahydrophenanthridine hydrochloride (DH-7), which have a nitrogen atom at 9-position of the morphinan ring, showed almost the same strong analgesic activities as morphine hydrochloride in a series of screening test.<BR> Further studies of the analgesic activity of DH-7 and the comparative pharmacological studies of the drug with morphine hydrochloride and levorphanol tartrate are described in this report. DH-7 has a chemical structure, shown in the following structural formula.