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EFFECT OF THE SALTS OF MESO-OXALIC ACID ON ALLOXAN DIABETES MELLITUS
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- KOBAYASHI YOSHITO
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- OHASHI SHIGERU
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- TAKEUCHI SETSUYA
- Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Description
Since the discovery of insulin, various new compounds having hypoglycemic action other than the pancreatic hormone have been reported. In 1922 Collip (1) reported Glucokinin and in 1927 Allen (2) Myrtillin, both of which are extracted from plants or yeast, and have hypoglycemic action. Best and Scott (1923) (3) stated that there are substances in the thyroid gland, liver and muscles that act in much the same way as insulin. Synthalin, a derivative of guanidin is effective but not in practical use, because of its marked side-action. That a kind of fatty acid containing seventeen C-atoms is effective against diabetes mellitus was reported by Kahn (1923) (4), but there was little evidence to support it. In 1945 Nath (6) reported he had succeeded in decreasing the acetone bodies in the blood of diabetics by using amellin.<BR> In Japan, proof has been found that there are substances which have hypogly-cemic action in seaweed, yeast and certain wild plants, but their chemical composition is totally unknown. In 1948 Kumagaya (5) reported he had discovered an acidic substance extracted from the Lathyrus Palustris L. var. Macranthus (white) Fernald and effective against diabetes mellitus.<BR> These findings so far reported led us to explore some unknown acidic compounds probably contained in plants, which might be efficacious in producing a marked decrease in the blood sugar level. This report deals with the hypoglycemic effect produced by the salts of meso-oxalic acid on the rabbit and dog having alloxap diabetes mellitus (10-18).
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 1 (1), 9-21, 1951
The Japanese Pharmacological Society
