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Effects of panax ginseng root on conditioned avoidance response in rats.
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- SAITO Hiroshi
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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- TSUCHIYA Moriyoshi
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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- NAKA Shinichi
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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- TAKAGI Keijiro
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
Bibliographic Information
- Other Title
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- Effect of Panax ginseng root on conditioned avoidance responce in rats
- Effect of Panax ginseng root on conditi
- Effects of Panax ginseng root on conditioned avoidance in rats
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Description
Pole climbing and shuttle box tests were employed to study conditioned avoidance response (CAR) and discrimination behaviour in Wistar male rats given extracts from Panax Ginseng root intraperitonealy. Neutral saponins (GNS), a water soluble fraction (GF4) which does not contain saponins, and a lipid soluble fraction (GNo. 5) inhibited CAR and discrimination ability between 500 Hz sound with electric shock (SD) and 1000 Hz sound without shock (SΔ). Small doses of GNo. 5 and ginsenoside Rg fraction (GRg) produced a slight shortening of the response latency (RL) to the conditioned stimulus in CAR. GNo. 5 produced the incorrect response to S ?? . Significant changes in the extinction of CAR were not evident with any fraction. Data from these tests indicate that Panax Ginseng root contains at least three sedative compounds.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 27 (4), 509-516, 1977
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679266722176
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- NII Article ID
- 130000839155
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- NII Book ID
- AA00691188
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- COI
- 1:STN:280:CSeD2cfpvVM%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL BIB ID
- 1837857
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- PubMed
- 926456
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed