Effects of 8-(2-dimethylaminoethyl)-3-oxo-4-phenyl-l-thia-4,8-diazaspiro-[4,5]decane dihydrochloride monohydrate (Y-8845) on carbon tetrachloride-induced liver injury
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- HATTA Shinichi
- Department of Pharmacology, Sapporo Medical College
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- SUZUKI Yuko
- Department of Pharmacology, Sapporo Medical College
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- MIYAMOTO Atsushi
- Department of Pharmacology, Sapporo Medical College
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- TAKEMURA Haruo
- Department of Pharmacology, Sapporo Medical College
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- OHSHIKA Hideyo
- Department of Pharmacology, Sapporo Medical College
書誌事項
- タイトル別名
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- Effects of 8-(2-dimethylaminoethyl)-3-oxo-4-phenyl-1-thia-4,8-diazaspiro (4,5) decane dihydrochloride monohydrate (Y-8845) on carbon tetrachloride-induced liver injury.
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説明
The effects of 8-(2-dimethylaminoethyl)-3-oxo-4-phenyl-1-thia-4, 8-diazaspiro [4, 5] decane dihydrochloride monohydrate (Y-8845) on carbon tetrachloride (CCl4)-induced liver injury were investigated in rats. CCl4-induced attenuation of the plasma cyclic AMP (cAMP) response to glucagon stimulation was significantly prevented by pretreatment with Y-8845. Y-8845 also effectively suppressed the increases in the activities of serum transaminases as well as the decreases in microsomal glucose-6-phosphatase activity and microsomal cytochrome P-450 concentrations induced by CCl4. In rats at 72 hr after CCl4 administration, the plasma cAMP response to glucagon, microsomal glucose-6-phosphatase activity and P-450 concentration were all below the control level. Y-8845 treatment after CCl4 administration rectified these reductions to nearly normal levels. Furthermore, Y-8845 stimulated DNA synthesis during liver regeneration after CCl4 intoxication. These results demonstrate that Y-8845 has a protective effect against CCl4-induced injury in the liver and a stimulating effect on the recovery of the damaged liver.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 40 (4), 561-567, 1986
公益社団法人 日本薬理学会
