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ADRENERGIC MECHANISM IN <I>TETRAHYMENA</I> III CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE AND CELL PROLIFERATION
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- KARIYA Kimio
- Department of Pharmacology, Faculty of Pharmacy, Kobe-Gakuin University
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- SAITO Katsuhisa
- New Product Planning and Development Division, Pharmaceutical Affairs, Takeda Chemical Industries LTD.
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- IWATA Heitaroh
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
Bibliographic Information
- Other Title
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- Adrenergic mechanism in Tetrahymena-3-Cyclic adenosine 3',5'-monophosphate and cell proliferation
- ADRENERGIC MECHANISM IN TETRAHYMENA III CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE AND CELL PROLIFERATION
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Description
The presence of cyclic adenosine 3', 5'-monophosphate (cAMP) in the ciliated protozoan, Tetrahymena pyrifurmis W, was demonstrated by thin-layer chromatography (TLC). The content of cAMP in the cell increased abruptly in the early exponential phase, and then diminished with further culture. When cells in the exponential or stationary growth phase were cultured in a fresh medium, growth was inhibited by addition of dibutyryl cAMP (Bt2-cAMP) or methylxanthines. In synchronized cultures of Tetrahymena, Bt2-cAMP inhibited protein and RNA syntheses in the G1 phase and DNA synthesis in the S phase. These results indicate that cAMP regulates the growth of the protozoan in the G1 phase.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 24 (1), 129-134, 1974
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679266932480
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- NII Article ID
- 130000838286
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE2cXkvVOrsrg%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 7673317
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed