EFFECTS OF GASTRIC ANTIBODIES ON GASTRIC SECRETION

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  • KAWASHIMA Koichiro
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
  • TAKAGI Keijiro
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

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  • Effects of gastric antibodies on gestric secretion-1-Production of rabbit antibodies against rat gastric mucosa and gastric juice
  • I. PRODUCTION OF RABBIT ANTIBODIES AGAINST RAT GASTRIC MUCOSA AND GASTRIC JUICE

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It has been shown that rabbits injected with a homogenate of rat gut mucosa produce auto-antibodies reacting with their own gut mucosa (1). Hausamen et al. (2) have demonstrated that the injection of an aqueous extract of guinea pig stomach into rabbits leads to the production of hetero- and auto-antibodies against parietal cell antigen, gastric intrinsic factor and mucous substances confined to the stomach. Hennes et al. (3) reported that antibodies, reacting with gastric juice and an extract of dog gastric mucosa, were found in dogs immunized with gastric juice from various sources. This paper describes the production of gastric antibodies to rat gastric antigens by the injection of rat gastric mucosa and gastric juice into rabbits, and characterization of these antibodies.

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