Possible involvement of cyclic AMP in inflammation induced by a surfactant.
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- FUTAMI Takahiro
- Household Products Research Laboratories, Kao Soap Co., Ltd.
書誌事項
- タイトル別名
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- Possible involvement of cyclic AMP in i
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抄録
Alkyldimethylbenzylammonium chloride (alkyl-DBAC), a cationic surfactant, produces acute exudative inflammation accompanied by an enhancement of energy metabolism. The mechanism of metabolic changes, consequently the cyclic AMP level and the effects of certain drugs were determined in the gastrocnemius muscles of rats in which acute exudative inflammation had been induced by intramuscular injections of alkyl-DBAC. A transient increase in the cyclic AMP level was noted at 15 to 30 minutes after the injection of alkyl-DBAC, and this elevation was antagonized by chlorpromazine, diphenhydramine, promethazine, aspirin and indomethacin. The time course of increasing tendency in the cyclic AMP level after the injection of histamine closely paralleled that of alkyl-DBAC. These results suggest that cyclic AMP may be involved in the metabolic changes with inflammation induced by alkyl-DBAC.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 27 (6), 763-767, 1977
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679267227392
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- NII論文ID
- 130000839230
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1cXotlGmtg%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 1916979
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- PubMed
- 204820
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可