INVOLVEMENT OF HISTAMINE H1- AND H2-RECEPTORS IN INDUCED ASTHMAS IN DOGS

DOI Web Site Web Site Web Site PubMed 被引用文献1件 参考文献20件

書誌事項

タイトル別名
  • Cardiotonic action of ring A-modified cardenolides, with special reference to cleavage of the ring.
  • Cardiotonic action of ring A modified c

この論文をさがす

抄録

Cardiotonic activities of six newly synthesized ring A-modified cardenolides, four 3, 5-seco-4-nor-cardenolides and two 4-oxa-cardenolides, were studied in isolated frog hearts and guinea pig atria. These compounds were 14-hydroxy-3, 5-seco-4-nor-5-oxo-l4β-card-20(22)-enolid-3-oic acid (IIa), and its methyl ester (IIb); 5β, 14 and 5α, 14-dihydroxy-3, 5-seco-4-nor-14β, -card-20(22)-enolid-3-ols (IIIa and IIIb); 3-dehydro-4-oxa-uzarigenin (IVa) and 3-dehydro-4-oxa-digitoxigenin (1Vb). In the frog heart (Straub's preparation), positive inotropic effects were demonstrated with all compounds except IIa. The pattern of response was the same as that to digitoxigenin (I). The relative potencies obtained on the basis of the concentration of each compound in which a contracture was brought about, the potency of I being taken as standard, were as follows: I (1.0), IIa (-), IIb (0.03-0.1), IIIa (0.01), IIIb (<0.01), IVa (<0.01), and IVb (0.03-0.1). The positive isotropic effect of IIb was also confirmed in guinea pig atria. IIb and IVb potentiated dose-dependently the K-contracture of the frog ventricular muscle just as was seen with I, indicating that the cardiotonic activity of the compounds is the same in nature as that of digitoxigenin. It was clearly demonstrated that the perhydrocyclopentanophenanthrene nucleus is not an indispensable requirement for cardiotonic activity.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 27 (6), 799-805, 1977

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ