Studies on the microcirculation in the rabbit ear chamber with a vital microscope. The process of new growth of vessels.

DOI 1 Citations 11 References
  • TODA Noriyuki
    Department of Dermatology, School of Medicine, The University of Tokushima
  • NAKANISHI Hideki
    Department of Dermatology, School of Medicine, The University of Tokushima

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Other Title
  • 生体顕微鏡法による微小循環の観察　創傷治癒過程における血管新生過程の観察を中心に
  • —The Process of New Growth of Vessels—
  • —創傷治癒過程における血管新生過程の観察を中心に—

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Abstract

Since angiogenesis is an important process of wound healing, the entire process of the new growth of vessels was microscopically investigated using a rabbit ear chamber. After installation of a transparent chamber on the ear, new capillary sprouts arose from the surrounding blood vessels on the edge of the table in 5 to 7 days. There were two types of sprouts. One was tapered and the other was saccular. After about 2 weeks, the sprouts formed capillary loops by fusion and new sprouts were produced from the loops. During the process, some capillaries were differentiated into arterioles and venules, while some remained as capillaries, and still others retracted and disappeared. The average time for complete vascularization of the table area was between 3 to 4 weeks after operation and then it was possible to clearly observe microcirculation in the capillary networks on the transparent chambers through a vital microscope over a period of several weeks. This technique can be a powerful tool for better understanding the process of wound healing.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 51 (6), 1157-1162, 1989

    Western Division of Japanese Dermatological Association

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