Inhibition Study of Darier's Sign with Oral Medicines in a Patient with Mastocytosis.

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  • SUGANO Shigeru
    Department of Dermatology, Nagoya City University Medical School
  • MORITA Akimichi
    Department of Dermatology, Nagoya City University Medical School
  • TSUJI Takuo
    Department of Dermatology, Nagoya City University Medical School

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  • 皮膚肥満細胞症に対する各種薬剤投与後のＤａｒｉｅｒ徴候の抑制の比較

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We attempted to inhibit Darier’s sign by the oral administration of anti-histamines, glucocorticoid, and dapsone in an 11-month-old patient with mastocytosis. We thus found ketotifen to most effectively inhibit Darier’s sign. We administered ketotifen to the patient for 6 months, thus resulting in a decreased plasma histamine level. These findings suggest that performing an inhibition study of Darier’s sign appears to be useful in selecting the optimal oral medicine for mastocytosis.

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