A Case of Prurigo Associated with Hepatitis C Virus-Induced Mixed Cryoglobulinemia.

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  • YAMAUCHI Ritsuko
    Department of Dermatology, Nagoya City University, Medical School
  • MORITA Akimichi
    Department of Dermatology, Nagoya City University, Medical School
  • TSUJI Takuo
    Department of Dermatology, Nagoya City University, Medical School

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  • Ｃ型肝炎の経過中に発生したクリオグロブリン血症によると考えられたよう疹の１例

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A man who developed prurigo associated with hepatitis C virus-induced mixed cryoglobulinemia is reported. Cryoglobulinemia has been reported to develop various cutaneous features. Our patient suffered from livedo racemosa and uncurable prurigo. Laboratory evaluations revealed a positive rheumatoid factor, a low CH50, a mixed cryoglobulinemia, and positive hepatitis C antibodies. The cryoglobulinemia was type II, which was composed of one monoclonal (IgMκ) and polyclonal immunoglobulin (IgG). Direct immunofluorcscence of a prurigo indicated IgG and IgM deposition in the upper dermis. These results suggest that cryoglobulinemia associated with hepatitis C virus infection may play a role in the development of prurigo in this case.

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