Xeroderma Pigmentosum with Diabetes Mellitus.
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- ARASE Seiji
- Department of Dermatology, Tokushima University School, of Medicine
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- NAKANISHI Hideki
- Department of Dermatology, Tokushima University School, of Medicine
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- FUJIMOTO Atsuo
- Department of Dermatology, Tokushima University School, of Medicine
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- NAGAE Hiroaki
- Department of Dermatology, Tokushima University School, of Medicine
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- SHIGEMI Fumio
- Department of Dermatology, Tokushima University School, of Medicine
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- TAKEDA Katsuyuki
- Department of Dermatology, Tokushima University School, of Medicine
Bibliographic Information
- Other Title
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- 糖尿病と尋常性乾癬の合併をみた色素性乾皮症
- Xeroderma pigmentosum with diabetes mellitus. A report of 2 cases plus clinical and biological studies of 8 cases of xeroderma pigmentosum occurring in Tokushima.
- —A Report of 2 Cases plus Clinical and Biological Studies of 8 Cases of Xeroderma Pigmentosum Occurring in Tokushima—
- —色素性乾皮症と内部臓器の老化についての考察—
Abstract
Two brothers with XP were found to be suffering from diabetes mellitus. The elder brother also had psoriasis vulgaris. XP is an autosomal recessive disease with an extensive heterogeneity in clinical features, and is characterized by cellular DNA repair deficiency. On the other hand, both ataxia telangiectasia and Fanconi’s anemia are also autosomal recessive syndromes characterized by certain DNA repair defects. And it has been well known that patients (homozygotes) with these syndromes frequently develop diabetes mellitus. These observations led us to suppose that XP patients may also be predisposed to DM. Clinical and biological studies of 8 patients with XP in Tokushima have been carried out. Three patients of rather an old age (older than 48) had diabetes mellitus, and one had a hyperlipemia. The number of patients analyzed was very small, but it should be noted that the frequency of DM in XP patients might be high. We also report the first case of XP occurring together with DM and psoriasis vulgaris in Japan.
Journal
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- Nishi Nihon Hifuka
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Nishi Nihon Hifuka 50 (5), 833-838, 1988
Western Division of Japanese Dermatological Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282679275106944
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- NII Article ID
- 130004695240
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- ISSN
- 18804047
- 03869784
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed