A Case of Acute Monocytic Leukemia with Skin Infiltration.

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  • 特異疹を認めた急性単球性白血病の１例

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A 76-year-old male was referred to us with a half month history of an asymptomatic erythematous lesion on his trunk. An increased percentage of monocytes (26%), promonocytes (10%), and monoblast (7%) were seen in a peripheral blood smear. Atypical cells were positive for CD 68 and lysozyme. Biopsy specimens showed the presence of a grenz zone consisting of normal connective tissue separating the normal epidermis from a diffuse infiltrate of atypical mononuclear cells in the upper half of the dermis. Atypical cells in the dermis had basophilic convoluted nuclei and eosinophilic cytoplasm. These cells were also found in the gingiva and bone marrow. The eruption disappeared after 7 days of chemotherapy for leukemia.

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