Aplastic Anemia is Suspected in a Patient with Pachydermoperiostosis

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  • SUZUKI Akiko
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • YAMAMOTO Ai
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • SHINTANI Yoichi
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • MORITA Akimichi
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • ISOGAI Zenzo
    Division of Dermatology, National Center for Geriatrics and Gerontology
  • HAYAMI Yoshihito
    Hematology, Department of Inter Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences
  • UEDA Ryuzo
    Hematology, Department of Inter Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences

Bibliographic Information

Other Title
  • 再生不良性貧血が疑われた皮膚骨膜肥厚症の１例
  • 症例 再生不良性貧血が疑われた皮膚骨膜肥厚症の1例
  • ショウレイ サイセイ フリョウセイ ヒンケツ ガ ウタガワレタ ヒフ コツマク ヒコウショウ ノ 1レイ

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Abstract

A 20-year-old man presented with deep wrinkles on his forehead and cheeks, cutis vertices gyrata of the scalp, clubbed digits, and bilateral painful joint swelling of the hands, ankles, and knees. There was no family history of similar symptoms. Clubbed digits were evident when he was in elementary school. Since the age of 16, he had been treated for polyarthritis in an orthopedic clinic. Examination of bone X-ray showed periosteal thickening of bones in the limbs and hands. Imaging analysis of the whole body showed nothing remarkable. From these findings, a diagnosis of primary pachydermoperiostosis was made. Anemia developed at the age of 25 years, followed by. thrombocytopenia at the age of 28 years. Examination of bone marrow aspirate revealed a dry tap. Bone marrow biopsy specimen was comprised of fatty replacement of marrow with little hematopoietic tissue. From these observations, aplastic anemia was suspected. Although anemia and thrombocytepenia initially improved with steroid therapy, blood values gradually worsened during tapering of steroid.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 69 (4), 382-386, 2007

    Western Division of Japanese Dermatological Association

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