Two Cases of Cutaneous Ulcer due to Povidone-iodine Solution

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  • ポビドンヨード液による皮膚潰瘍の２例
  • 症例 ポビドンヨード液による皮膚潰瘍の2例
  • ショウレイ ポビドンヨードエキ ニ ヨル ヒフ カイヨウ ノ 2レイ

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Abstract

We report two cases of cutaneous ulcer caused by application of povidone-iodine solution over a long period. Case 1: A 46-year-old man in whom erythema with bulla formation on an amputation stump of the right lower leg was diagnosed as herpes infection in June 2004 developed multiple ulcers after application of 10% Isodine®solution and Cadex®ointment over a period of two months. Case 2: A 72-year-old man who underwent an operation for phimosis in October 2005 developed an ulcer of the glans penis after application of Isodine®Kizugusuri for a period of one month. In 48-hour closed patch tests with antiseptic and/or antibacterial agents and several topical applications, Isodine® solution as is, Cadex®ointment as is and U-Pasta®ointment as is showed positive reactions in Case 1, and Isodine® solution as is, 10% aq and Cadex®ointment as is showed positive reactions in Case 2. In both cases, the positive reactions of povidone-iodine preparations on day 3 were stronger than those on day 2 and continued until day 7. We diagnosed both cases as irritant and allergic contact dermatitis and ulceration. When a cutaneous ulcer has not healed within a few weeks, patch tests with antiseptics should be performed.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 69 (4), 375-381, 2007

    Western Division of Japanese Dermatological Association

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