A Case of Uveitis and Poliosis with Metastatic Malignant Melanoma.

DOI 11 References
  • MUROI Eiji
    Department of Dermatology, Nagasaki University School of Medicine
  • HAMASAKI Youichirou
    Department of Dermatology, Nagasaki University School of Medicine
  • DOI Takashi
    Department of Dermatology, Nagasaki University School of Medicine
  • ABE Yoko
    Department of Dermatology, Nagasaki University School of Medicine
  • UDONO Masako
    Department of Dermatology, Nagasaki University School of Medicine
  • KATAYAMA Ichiro
    Department of Dermatology, Nagasaki University School of Medicine
  • SAITOH Akira
    Department of Ophthalmology, Nagasaki University School of Medicine

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Other Title
  • ぶどう膜炎，白毛を伴った転移性悪性黒色腫の１例

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A 55-year-old woman presented with a subcutaneous tumor in her left inguinal region in 1998. An aspiration biopsy of the mass demonstrated tissue consistent with metastatic malignant melanoma. A surgical excision of the tumor was performed in 1999. An extensive search failed to identify the primary lesion. At the time of the initial tumor developement, the patient had poliosis of the scalp. Approximately 3 months after the developing the tumor, she noticed a visual disturbance in her right eye. Uveitis and optic neuritis were diagnosed, and the patient was followed up without any treatment. Vitiligo may thus be an immunologically mediated by melanocyte destruction. Circulating antibodies to the melanocytes have been found in some patient with vitiligo. Ocular abnormalities occurring in depigmented patients have been reported to be especially common when leukoderma is associated with cutaneous melanoma. Therefore, our present report suggests that the autoimmune system plays an important role in the occurence of poliosis and uveitis associated with malignant melanoma. In addition, the presence of hypopigmentation and uveitis has a positive influence on the prognosis of patients with malignant melanoma.

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