Treatment of Patients with Darier’s Disease with Topical Application of Solbase (a Mixture of Polyethylene Glycol 400 & 4000) Plus Occlusion
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- ARASE Seiji
- Department of Dermatology, Tokushima University School of Medicine
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- NAKANISHI Hideki
- Department of Dermatology, Tokushima University School of Medicine
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- NAGAI Ryu
- Department of Dermatology, Tokushima University School of Medicine
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- TAKEDA Katsuyuki
- Department of Dermatology, Tokushima University School of Medicine
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- IMURA Hiroshi
- Imura Dermatological Clinic
Bibliographic Information
- Other Title
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- ダリエ病に対するポリエチレングリコールODT療法
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Abstract
Topical application of Solbase (a mixture of polyethylene glycol 400 & 4000) plus occlusion improved the eruptions of 2 patients with Darier’s disease. To determine the mechanism of action, the effect of polyethelene glycol 400 on the rat epidermal DNA synthesis was investigated using autoradiography and doing 14C-thymidine incorporation studies. Seven days’ topical application of polyethylene glycol 400 activated epidermal DNA synthesis nearly double the value seen in the control. This therapy should be considered for patients with Darier’s disease and especially for whom retinoids cannot be prescribed.
Journal
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- Nishi Nihon Hifuka
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Nishi Nihon Hifuka 49 (2), 290-295, 1987
Western Division of Japanese Dermatological Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282679276807040
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- NII Article ID
- 130004695126
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- ISSN
- 18804047
- 03869784
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed