Study of Weekday-Weekend Therapy with Maxacalcitol Ointment for Psoriasis Vulgaris

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  • KATOH Norito
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medicine Science
  • KISHIMOTO Saburo
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medicine Science
  • FUKUCHI Osamu
    Department of Dermatology, The Jikei University School of Medicine
  • OTA Mayumi
    Department of Dermatology, The Jikei University School of Medicine
  • HONDA Mariko
    Department of Dermatology, The Jikei University School of Medicine
  • NAKAGAWA Hidemi
    Department of Dermatology, The Jikei University School of Medicine

Bibliographic Information

Other Title
  • 尋常性乾癬に対するマキサカルシトール軟膏による平日・週末療法の検討
  • 治療 尋常性乾癬に対するマキサカルシトール軟膏による平日・週末療法の検討
  • チリョウ ジンジョウセイ カンセン ニ タイスル マキサカルシトール ナンコウ ニ ヨル ヘイジツ シュウマツ リョウホウ ノ ケントウ

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Abstract

Twenty-nine patients with psoriasis were treated topically with vitamin D3 derivative maxacalcitol ointment (Oxarol® Ointment, 25 μg/g), which was applied once daily on weekdays and twice daily on Saturdays and Sundays (hereinafter, weekday-weekend therapy). Treatment was continued for 12 weeks in 3 stages. On the basis of the improvement ratings obtained in the first stage (4 weeks of weekday-weekend therapy), regimens for the second and third stages were determined. Eighteen patients achieved maintenance with the maxacalcitol ointment alone throughout the study period, whereas 10 patients received a combination of the ointment and a topical corticosteroid after the second stage; the condition was controllable with the maxacalcitol ointment alone for 64.3% patients. For the remaining 35.7% of patients, control of the eruptions with the topical vitamin D3 preparation alone was difficult and concomitant use of the topical corticosteroid was required. The mean PSI score improvement rate at the end of treatment was 74.8% for patients receiving maxacalcitol ointment alone and 56.0% for patients receiving topical corticosteroid in combination with the ointment. For the entire study population, the PSI score improvement rate after 12 weeks of treatment was high at 68.1%. A patient questionnaire revealed an increase in the ratio of patients able to administer the topical application as directed by the physician, from 70.0% at baseline to 95.0% after treatment. The ratio of patients who complained of stress from problems regarding topical drug application decreased from 65.0% at baseline to 35.0% after treatment. These results suggest that topical application therapy based on a weekday-weekend regimen might improve compliance and quality of life for psoriasis patients.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 70 (5), 527-534, 2008

    Western Division of Japanese Dermatological Association

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