Two Cases of Giant Condyloma Acuminatum Effectively Treated with Zinc Oxide Starch Powder

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  • YASUKAWA Fumiko
    The Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • KUDO Kyoko
    The Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • NAKAMURA Akiko
    The Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • KOBAYASHI Shinji
    The Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • URABE Kazunori
    The Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • IMAYAMA Shuhei
    IMAYAMA LAB. Skin and Allergy Clinic

Bibliographic Information

Other Title
  • 亜鉛華デンプンによる治療が有効であった巨大尖圭コンジローマ（Ｇｉａｎｔ　Ｃｏｎｄｙｌｏｍａ　Ａｃｕｍｉｎａｔｕｍ）の２例
  • 症例 亜鉛華デンプンによる治療が有効であった巨大尖圭コンジローマ(Giant Condyloma Acuminatum)の2例
  • ショウレイ アエンカ デンプン ニ ヨル チリョウ ガ ユウコウ デ アッタ キョダイ セン ケイ コンジローマ Giant Condyloma Acuminatum ノ 2レイ

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Abstract

Condyloma acuminatum is caused by mucous-specific types of human papilloma virus infection. Especially, Giant condyloma acuminatum is rare, and in many cases it is very difficult to treat. Zinc oxide starch powder mainly consists of Zinc oxide and starch powder. Zinc oxide provides 1) astringency, 2) a protective effect and 3) an antibiotic effect. Starch powder has an absorbent effect. So we proposed that Zinc oxide powder could change the moist environment in the genital region and that it could suppress a proliferation of virus that would lead to a decrease in the tumor size. Here, we report two cases of Giant condyloma acuminatum of the genital region that were effectively treated with Zinc oxide starch powder. A 20-yearold woman presented with a giant cauliflower-like tumor of the perianal region. She had had treatment with topical 5-fluorouracil for about 1 year. She also had been treated for SLE with corticosteroid. After 8 months treatment with topical Zinc oxide starch powder and administration of coix extract, the tumor disappeared with small scars. Also, a 38-year-old man was hospitalized with a giant cauliflower-like tumor on the penis and in the genital area. We also found that he had severe untreated diabetes. He used to be treated with podophyllin. A partial excision of the lesion was performed. After 7 months of topical application of Zinc oxide starch powder and administration of coix extract, the residual tumor collapsed. We propose that Zinc oxide starch powder is a good treatment option because it is 1) painless, 2) easy to handle by patients, 3) useable with other general treatment options, and also 4) inexpensive and commercially available.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 72 (2), 121-125, 2010

    Western Division of Japanese Dermatological Association

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