Evaluation of the Efficacy of Olopatadine Hydrochloride in Pruritic Skin Diseases-An Attempt at Early Prediction of Itch Control by Decreasing Ratio of VAS Values (VAS before treatment/VAS after treatment)-

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  • そう痒性皮膚疾患に対するオロパタジン塩酸塩の有用性の検討―ＶＡＳの減少率からみたかゆみコントロールの早期予測の試み―
  • 掻痒性皮膚疾患に対するオロパタジン塩酸塩の有用性の検討--VASの減少率からみたかゆみコントロールの早期予測の試み
  • ソウ ヨウセイ ヒフ シッカン ニ タイスル オロパタジン エンサンエン ノ ユウヨウセイ ノ ケントウ VAS ノ ゲンショウリツ カラ ミタ カユミ コントロール ノ ソウキ ヨソク ノ ココロミ
  • Evaluation of the Efficacy of Olopatadine Hydrochloride in Pruritic Skin Diseases
  • —An Attempt at Early Prediction of Itch Control by Decreasing Ratio of VAS Values (VAS before treatment/VAS after treatment)—
  • ――VASの減少率からみたかゆみコントロールの早期予測の試み――

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Abstract

OBJECTIVE : To evaluate the efficacy of the H1-antihistamine, olopatadine hydrochloride in the treatment of acute and chronic pruritic skin diseases, and to determine the usefulness of decreasing ratio of visual analogue scale (VAS) values (VAS before treatment/VAS after treatment) as an early prediction tool of itch control. METHODS : One hundred and eighteen patients suffering from acute and chronic pruritic skin disorders such as atopic dermatitis (AD), eczema, and urticaria were treated with oral administration of olopatadine hydrochloride (5 mg, twice a day) for more than 2 weeks. Effectiveness of the treatment was evaluated by the ratio of VAS values before and after treatment. Satisfaction levels of the patients were also assessed by questionnaire. RESULTS : In all patient groups of AD, eczema and urticaria, over 50% of patients showed a decrease in VAS ratios to 30% and below at the first visit (within 2 weeks) after starting treatment with olopatadine hydrochloride. Increased satisfaction levels of the patients were also observed. When patients were divided into two groups (VAS value ratios over 30% or below 30% at the first visit after treatment), the mean VAS value ratio before treatment was not significantly different between the two groups. But when effectiveness of the treatment was evaluated based on individual decreasing ratios of VAS values at the first visit after treatment, a tendency of insufficient itch control was observed in the patients whose VAS value ratios were below 50%. CONCLUSIONS : These results suggest that olopatadine treatment shows effectiveness in pruritic skin diseases within 2 weeks. Our data also indicate that a decreasing ratio of VAS values might serve as an early prediction tool of itch control after H1-antihistamine treatment.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 72 (2), 169-175, 2010

    Western Division of Japanese Dermatological Association

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