Efficacy and Safety of Liranaftate Cream Combined with 5% Salicylic Acid Ointment for Hyperkeratotic Tinea Pedis

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  • TAKENAKA Motoi
    Department of Dermatology and Allergy, Nagasaki University Hospital of Medicine and Dentistry
  • SATO Shinichi
    Department of Dermatology and Allergy, Nagasaki University Hospital of Medicine and Dentistry
  • NISHIMOTO Katsutaro
    Japan Seafarers Relief Association Nagasaki Hospital

Bibliographic Information

Other Title
  • 角質増殖傾向の著明な足白癬に対するリラナフタート（ゼフナート）クリーム・サリチル酸ワセリン併用療法の臨床的検討
  • 治療 角質増殖傾向の著明な足白癬に対するリラナフタート(ゼフナート)クリーム・サリチル酸ワセリン併用療法の臨床的検討
  • チリョウ カクシツ ゾウショク ケイコウ ノ チョメイナ ソクハクセン ニ タイスル リラナフタート ゼフナート クリーム サリチルサン ワセリン ヘイヨウ リョウホウ ノ リンショウテキ ケントウ

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Abstract

Hyperkeratotic tinea pedis is intractable. Since complete remission by topical therapy with antifungal agents alone is difficult to secure, concomitant use of oral antifungal drugs is required in many cases. On the other hand, there are many elderly patients with hyperkeratotic tinea pedis, and physicians are often reluctant to use oral antifungal drugs because of problems with concomitant use of other drugs and side effects. Therefore, occlusive dressing techniques and combined therapy with urea ointment have been attempted, and 70-80% efficacy was reported. We examined the effect and safety of liranaftate cream combined with 5% salicylic acid ointment administered for 8 weeks in 16 patients with hyperkeratotic tinea pedis. In the clinical assessment of skin symptoms, prominent improvement was seen in 31.3%, moderate improvement in 31.3%, and slight improvement in 37.4% of the patients. As for the transition of the skin symptom score, we compared “scale” and “hyperkeratosis” and found a significant decrease in 8 weeks after. On the other hand, the score for “erythema” and “itching” hardly changed after treatment. The mycological improvement was 86.7%. When improvement of both skin symptoms and the results of fungus findings were considered for the overall evaluation of efficacy, the therapy was assessed as useful or highly effective in 81.3% of the patients. No side effects were observed in any patient during or after treatment, not even skin irritability due to salicylic acid ointment. Since salicylic acid ointment is also recommended for tinea pedis by health insurance providors, it seemed worthwhile to attempt its use as combination therapy with Liranaftate for hyperkeratotic tinea pedis.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 70 (2), 208-212, 2008

    Western Division of Japanese Dermatological Association

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