Studies on Adrenocortical Suppression Following Percutaneous Absorption of Topical Corticosteroids

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  • SHIMAO Shuhei
    Department of Dermatology, Tottori University School of Medicine
  • SHIMIZU Yasuyuki
    Department of Dermatology, Tottori University School of Medicine
  • ASO Miki
    Department of Dermatology, Tottori University School of Medicine
  • MIHARA Motoyuki
    Department of Dermatology, Tottori University School of Medicine
  • INOUE Taeko
    Department of Dermatology, Tottori University School of Medicine
  • KANBE Naoto
    Department of Dermatology, Tottori University School of Medicine
  • KIMURA Ryoichi
    Kimura Private Clinic
  • USUI Toshiaki
    Division of Chemistry, Institute of Steroid Research, Tottori University School of Medicine
  • KAWAMOTO Hiroko
    Division of Chemistry, Institute of Steroid Research, Tottori University School of Medicine

Bibliographic Information

Other Title
  • 外用コルチコステロイド経皮吸収による副腎皮質機能抑制の検討
  • 外用コルチコステロイド経皮吸収による副腎皮質機能抑制の検討--密封包帯法による0.1%Triamcinolone Acetonide軟膏(0.1%Ledercort軟膏)の場合
  • ガイヨウ コルチコステロイド ケイヒ キュウシュウ ニヨル フクジン ヒシツ
  • 外用コルチコステロイド経皮吸収による副じん皮質機能抑制の検討
  • —Observations on 0.1% Triamcinolone Acetonide Ointment (Ledercort ointment) Applied under Occlusive Dressing—
  • ―密封包帯法による0.1% Triamcinolone Acetonide軟膏(0.1% Ledercort軟膏)の場合―

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Abstract

Three patients with generalized psoriasis, a patient with chronic eczematous dermatitis and a patient with exfoliative dermatitis were treated with 0.1% triamcinolone acetonide ointment (Ledercort oint.), 20g/day, (20mg. triamcinolone acetonide) under ODT. The serum 11-OHCS and urinary 17-OHCS levels were estimated every day. Eosinophil counts and blood glucose levels were also determined. The serum 11-OHCS and urinary 17-OHCS levels were slightly lowered or unchanged in all cases during observation. The phenomenon of inhibition of adrenocortical function was slight and the levels of serum 11-OHCS were limited in normal range. A decreasing tendency of eosinophil counts and increasing of blood glucose levels were observed in one case respectively. ODT with 0.1% triamcinolone acetonide ointment showed clinical usefulness. It seems reasonable to conclude from the above resusts that the patient with chronic skin disease, e. g. psoriasis, would be better treated with this ointment in external application.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 37 (3), 410-419, 1975

    Western Division of Japanese Dermatological Association

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