The Effect of Kojic Acid on Yellowish Discoloration

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  • コウジ酸の顔面黄ぐすみに対する改善効果
  • コウジサン ノ ガンメン オウグスミ ニ タイスル カイゼン コウカ

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We have previously conducted clinical studies using Kojic Acid (KA) to treat melasma, solar lentigo, nevus Ota, ephelides,pigmented cosmetic dermatitis, and other pigmentation disorders over the past 35 years. Interestingly, many of the patients treated with KA showed improvement not only in pigmentation but also in yellowish hue and reduced-translucency of the skin,here termed‘yellowish discoloration’. Recently, advanced glycation end products (AGEs) produced by glycation of proteins,and advanced lipoxidation end products (ALEs) produced by carbonyl modification of proteins have been considered to be a cause of yellowish discoloration. The clinical evidence of the effect of KA on improving yellowish discoloration of the skin encouraged us to investigate the effect of KA on AGEs/ALEs production, and we have found that KA plays an important role in inhibiting AGEs/ALEs production in both the epidermis and dermis. Therefore, it is suggested that KA treatment can effectively produce improvement not only in pigmentation disorders but also in those with yellowish discoloration of the skin.

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