A Case of Hallopeau Type Pemphigus Vegetans Successfully Treated with High-dose Intravenous Immunoglobulin(IVIG)Therapy
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- YAGI Nobutake
- Department of Dermatology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center
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- YAMAGUCHII Sayaka
- Department of Dermatology, Graduate School of Medicine, University of the Ryukyus
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- TAKAHASHI Kenzo
- Department of Dermatology, Graduate School of Medicine, University of the Ryukyus
Bibliographic Information
- Other Title
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- 免疫グロブリン大量静注療法(IVIG)が著効した Hallopeau 型増殖性天疱瘡の 1 例
- 症例 免疫グロブリン大量静注療法(IVIG)が著効したHallopeau型増殖性天疱瘡の1例
- ショウレイ メンエキ グロブリン タイリョウ ジョウチュウ リョウホウ(IVIG)ガ チョコウシタ Hallopeauガタ ゾウショクセイ テンポウソウ ノ 1レイ
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Abstract
<p>An 83-year-old woman had complained of pain of her genital region for one month. She was suspected of having a malignant tumor at a nearby clinic and was admitted to our hospital for further examination. At her first visit, verrucous vegetation was seen on the entire genital region. After a limited time, erosions at the axilla and lips and thickening of the tongue also appeared. Histologically, acanthosis and a microabscess containing numerous eosinophils were observed at the lesional epidermis. Direct immunofluorescence analysis revealed the deposition of IgG at keratinocyte surfaces. Her serum levels of anti-desmoglein (Dsg) 1 and anti-Dsg3 antibodies were elevated. Based on clinical, histological, and laboratory findings, this case was diagnosed as Hallopeau type pemphigus vegetans. Although she developed a widespread erosion that was not well controlled with oral corticosteroids only, the erosion was controlled by combining corticosteroids with high-dose intravenous immunoglobulin therapy.</p>
Journal
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- Nishi Nihon Hifuka
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Nishi Nihon Hifuka 79 (6), 552-557, 2017
Western Division of Japanese Dermatological Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282679277769216
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- NII Article ID
- 130006386618
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- NII Book ID
- AN00183881
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- ISSN
- 18804047
- 03869784
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- NDL BIB ID
- 028765484
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed