A Case of Myeloid Sarcoma Presenting as Brown Nodule in a Young Woman

TOMIDA Etsuko, TAKEUCHI Aya, INDEN Mai, OHNO Toshiyuki, KAYO Orie, SHIMIZU Makoto

doi:10.2336/nishinihonhifu.78.262

We report a case of myeloid sarcoma on the nipple. The patient was a 31-year-old Japanese woman without blood disease. Eight months before her first visit to our clinic, she was operated on for a breast tumor, which she was aware of for 3 months beforehand. Five months after the operation, a brown nodule appeared on the scar. At her first visit to us, she presented with the chief complaints of the brown nodule on her nipple and a subcutaneous nodule in her breast. Hematoxylin-eosin staining revealed atypical enlarged cells with a high nuclear/cytoplasmic ratio densely infiltrating the dermis. Immunohistochemical staining was positive for CD68 and CD117, and negative for CD3, CD4, CD10, CD20, CD34, and CD56. Biopsy specimens from bone marrow showed no abnormal cells. From these findings, we diagnosed myeloid sarcoma. Two months later, she was administered chemotherapy with intravenous idarubicin hydrochloride and cytarabine at another hospital. After two courses of chemotherapy, she was not in clinical remission. At her own decision, she stopped receiving treatment for 5 months. Then, she visited the hematology department at our hospital and was diagnosed with leukemia. She was treated with mitoxantrone and cytarabine, and will undergo bone marrow transplantation.

A Case of Myeloid Sarcoma Presenting as Brown Nodule in a Young Woman

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