Familial Confluent and Reticulated Papillomatosis in Siblings

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  • 融合性細網状乳頭腫症の兄妹例
  • 症例 融合性細網状乳頭腫症の兄妹例
  • ショウレイ ユウゴウセイサイモウジョウ ニュウトウ シュショウ ノ アニ マイレイ

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The etiology of confluent and reticulated papillomatosis (CRP) is unknown, and there have been only a few case reports of familial CRP in the world to date. We herein report two cases of familial CRP successfully treated with tetracyclines. A 19-year-old male patient presented with a 2-year history of mildly pruritic brown macules and reticulated plaques over the trunk. Malassezia was found on KOH examination. He was initially diagnosed with pityriasis versicolor and was treated with antifungals. No improvement was noted, and a skin biopsy was performed. The histopathological findings revealed epidermal hyperkeratosis with acanthosis, papillomatosis, and perivascular lymphocytic infiltration in the dermis. A diagnosis of CRP was made. Minocycline (200 mg/ day) was started, and there was a remarkable improvement within 4 weeks. Treatment was stopped 14 weeks after the diagnosis, but recurrence was observed 6 weeks later. His 17-year-old sister had similar brown macules and patches over the trunk for 18 months. KOH examination was negative. A diagnosis of CRP was made based on clinical findings and a skin biopsy specimen. She was successfully treated with doxycycline (100 mg/ day) for 8 weeks. The skin lesions had been clear for 4 weeks when a recurrence was noted. Although the symptoms recurred, we observed improvement in both cases with the successive tetracycline treatment.

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