A Comparative Study of Adult-onset Anaphylactoid Purpura Associated with Malignancy and without Malignancy

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  • SAITO Akimasa
    Department of Dermatology, Faculty of Medicine, University of Tsukuba
  • FUJISAWA Yasuhiro
    Department of Dermatology, Faculty of Medicine, University of Tsukuba
  • NAKAMURA Yoshiyuki
    Department of Dermatology, Faculty of Medicine, University of Tsukuba
  • FURUTA Junichi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba
  • KAWACHI Yasuhiro
    Department of Dermatology, Faculty of Medicine, University of Tsukuba
  • OTSUKA Fujio
    Department of Dermatology, Faculty of Medicine, University of Tsukuba

Bibliographic Information

Other Title
  • 当科で経験した悪性腫瘍を合併した成人アナフィラクトイド紫斑の 6 例と 非合併例 13 例との比較
  • 統計 当科で経験した悪性腫瘍を合併した成人アナフィラクトイド紫斑の6例と非合併例13例との比較
  • トウケイ トウ カ デ ケイケン シタ アクセイ シュヨウ オ ガッペイ シタ セイジン アナフィラクトイド シハン ノ 6レイ ト ヒガッペイレイ 13レイ ト ノ ヒカク

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Abstract

Adult-onset anaphylactoid purpura (AP) is known to be associated with malignancy. However, few reports have described the clinical differences between adult-onset AP with malignancy and that without malignancy. We retrospectively reviewed data from 19 adult-onset cases of AP between 2004 and 2012 in our department and categorized them into two groups to compare their clinical features and managements : a malignancy group (group A : 6 cases) and a non-malignancy group (group B : 13 cases). In group A, all the patients had solid tumors and 3 cases (50%) were diagnosed as AP at the time of or prior to the discovery of malignancy. There were no significant differences between the two groups in the incident of precursory infections, arthralgia, gastrointestinal symptoms, or widespread purpura ranging beyond the lower limbs. The incident of renal dysfunction was significantly higher in group A than in group B (P＜0.05). There were no significant differences between the two groups in the level of serum IgA and ASO. In group A, systemic steroid therapy mainly applied to renal dysfunction. We should be aware of the possibility of underlying malignancy when we encounter adult-onset AP. Because of the high rate of renal dysfunction, careful observation is recommend for adult-onset AP patients with malignancy.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 76 (5), 487-492, 2014

    Western Division of Japanese Dermatological Association

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