Combination Effects of Kampo Prescriptions, Japanese Herbal Medicines and Conventional Therapy in Atopic Dermatitis Patients : Comparison between Unseiin and Shimotsuto

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  • KOBAYASHI Hiromi
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • YANAGIHARA Shigeto
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • TAMIYA Hisashi
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • NAKANISHI Takeshi
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • MIZUNO Nobuyuki
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • TSURUTA Daisuke
    Department of Dermatology, Osaka City University Graduate School of Medicine
  • ISHII Masamitsu
    Department of Dermatology, Osaka City University Graduate School of Medicine

Bibliographic Information

Other Title
  • アトピー性皮膚炎患者の自他覚症状に対する漢方薬の併用効果 ―― 温清飲と四物湯の比較試験 ――
  • 治療 アトピー性皮膚炎患者の自他覚症状に対する漢方薬の併用効果 : 温清飲と四物湯の比較試験
  • チリョウ アトピーセイ ヒフエン カンジャ ノ ジタカク ショウジョウ ニ タイスル カンポウヤク ノ ヘイヨウ コウカ : オン セイイン ト ヨンブツ ユ ノ ヒカク シケン

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Abstract

We investigated the efficacy of four weeks of treatment with either of the Kampo prescriptions, Japanese herbal medicines, unseiin or shimotsuto on subjective symptoms such as pruritus, severity of the skin disease, and quality of life (QOL) in atopic dermatitis patients. These patients had at least medium-grade symptoms that had not improved following previous standard treatments. There were eight patients in the unseiin group and seven in the shimotsuto group. There was significant improvement in all of the surveyed subjective symptoms, such as pruritus, a feeling of skin dryness, and sleep disorders in the unseiin group. In contrast, no significant improvement in subjective symptoms was recognized in the shimotsuto group. In particular, there was a significant difference in the change from baseline in the feeling of skin dryness between the two treatments. The SCORAD score, which is an index of the severity of skin disease symptoms, showed significant improvement only in the unseiin group. No significant change was seen in the level of the Th2 chemokine TARC before and after treatment in either group. However, one patient in the unseiin group who presented with medium-grade symptoms prior to treatment developed a slight illness after the treatment. In a QOL evaluation using the Skindex-16 questionnaire, the categories of “Total”, “Symptom”, and “Feelings” showed meaningful improvements in the unseiin group, and those of “Total”, “Feelings”, and “Function” showed meaningful improvements in the shimotsuto group. The categories that showed the most improvement in the unseiin group were “Symptom” and “Feelings.” Unseiin is produced from the common crude drugs of both orengedokuto and shimotsuto. Orengedokuto has anti-inflammatory effects, while shimotsuto has moisturizing effects. In summary, the results indicated that unseiin could reduce dermatitis more effectively than shimotsuto, and both of these treatments contributed to improving QOL in atopic dermatitis patients.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 78 (2), 171-176, 2016

    Western Division of Japanese Dermatological Association

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