Autoimmune Blistering Disease with Concurrent IgG Antibodies to Desmoglein 1 and BP180 : Two Cases

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  • ICHIKAWA Miki
    Division of Dermatology, Haradoi Hospital
  • TANAKA Maya
    Division of Dermatology, Haradoi Hospital
  • URABE Kazunori
    Department of Dermatology, National Hospital Organization Kyushu Medical Center
  • FURUE Masutaka
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • 抗デスモグレイン 1 抗体と抗 BP180 抗体を同時期に検出した自己免疫性水疱症の 2 例
  • 症例 抗デスモグレイン1抗体と抗BP180抗体を同時期に検出した自己免疫性水疱症の2例
  • ショウレイ コウデスモグレイン 1 コウタイ ト コウBP180 コウタイ オ ドウ ジキ ニ ケンシュツ シタ ジコ メンエキセイ スイホウショウ ノ 2レイ

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Description

We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected by enzymelinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 75 (5), 415-418, 2013

    Western Division of Japanese Dermatological Association

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