Efficacyof IKD-382 Cream for Tinea Pedis with Hyperkeratotic Lesions

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  • MOCHIZUKI Takashi
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • ABE Shinya
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • TANABE Hiroshi
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • USHIGAMI Tsuyoshi
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • KOJIMA Kiyoto
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • NANBU Masayuki
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • SAKAMOTO Tomoko
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • KAWANISHI Junko
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • HATTA Junko
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • ANZAWA Kazushi
    Department of Dermatology, Faculty of Medicine, Kanazawa Medical University
  • NAKAMURA Tomoya
    Department of R&D Center, Ikeda Mohando Co., Ltd.
  • YOSHIDA Naoki
    Department of R&D Center, Ikeda Mohando Co., Ltd.
  • OGAWA Kazuo
    Department of R&D Center, Ikeda Mohando Co., Ltd.

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Other Title
  • 角質増殖性病変をともなう足白癬に対する IKD-382 クリームの使用経験
  • 治療 角質増殖性病変をともなう足白癬に対するIKD-382クリームの使用経験
  • チリョウ カクシツ ゾウショクセイ ビョウヘン オ トモナウ アシ ハクセン ニ タイスル IKD-382 クリーム ノ シヨウ ケイケン

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Clinical trials of topical therapeutics targeted on tinea pedis with hyperkeratotic lesions, which is assumed to resist to topical therapies, are lacking. In this study, we assessed the effectiveness and safety of IKD-382 cream, which consists of 1.0% terbinafine hydrochloride, for eight weeks against tinea pedis with hyperkeratotic lesions. The study was made by objective examination of skin lesions by specialists of dermatology, subjective findings, mycological tests and safety. Of the 36 cases registered, 29 cases were evaluated for analysis of effectiveness. As a result, 100% of the patients scored improvement above moderate for general improvement, 79.3% showed negative studyfor mycological tests, and 79.3% scored more than effective in overall effectiveness. In addition, no side effects were observed in all 36 cases. The improvement effect on scale and hyperkeratosis was particularly remarkable in clinical manifestations, and improvements more than two steps were recognized in 18 cases of 29. The IKD-382 cream was proved to show constant effectiveness and safety, and it was shown as an effective device for tinea pedis with hyperkeratotic lesions.

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