Photochemical Oxidation of Poly(dimethylsiloxane) Surface and Subsequent Coating with Biomimetic Phosphorylcholine Polymer
-
- Hamada Yoshiteru
- Department of Materials Engineering, School of Engineering, The University of Tokyo
-
- Ono Takao
- Department of Bioengineering, School of Engineering, The University of Tokyo
-
- Akagi Takanori
- Department of Bioengineering, School of Engineering, The University of Tokyo Center for NanoBio Integration, The University of Tokyo
-
- Ishihara Kazuhiko
- Department of Materials Engineering, School of Engineering, The University of Tokyo Department of Bioengineering, School of Engineering, The University of Tokyo Center for NanoBio Integration, The University of Tokyo
-
- Ichiki Takanori
- Department of Materials Engineering, School of Engineering, The University of Tokyo Department of Bioengineering, School of Engineering, The University of Tokyo Center for NanoBio Integration, The University of Tokyo
この論文をさがす
抄録
As a material for fabricating biomicrosystem devices called lab-on-a-chip or micro total analysis system (μTAS), poly(dimethylsiloxane) (PDMS) has been widely used. Generally, the devices used in biological applications require some surface modification in order to control the hydrophilicity and nonspecific adsorption of biomolecules on their surfaces. However, it is difficult to achieve surface modification that remains sufficiently stable over long enough duration for use in PDMS microfluidic devices. In this paper, we report a simple but reliable method of applying a surface coating of biomimetic polymer to PDMS surfaces by the combinative use of photochemical surface oxidation by VUV irradiation and subsequent coating of phospholipid copolymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC) and 3-methacryloxytriethoxysilane (METESi). The effectiveness of this coating process has been demonstrated by a significant reduction in the nonspecific adsorption of serum albumin and the formation of a micropatterned surface coating using a photomask.
収録刊行物
-
- Journal of Photopolymer Science and Technology
-
Journal of Photopolymer Science and Technology 20 (2), 245-249, 2007
フォトポリマー学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679300927616
-
- NII論文ID
- 130004464536
- 40015602483
-
- NII書誌ID
- AA11576862
-
- COI
- 1:CAS:528:DC%2BD2sXot1WntbY%3D
-
- ISSN
- 13496336
- 09149244
-
- NDL書誌ID
- 8918821
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可