Cell analysis using Photodegradable Nanoparticles

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  • Kato Masaru
    Graduate School of Pharmaceutical Sciences and GPLLI Program, The University of Tokyo

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We have recently developed protein encapsulated nanoparticle that can be photocleaved with ultraviolet (UV) light. Biological activities of protein restricted by nanoparticle encapsulation were recovered by applying external light to the nanoparticle. We succeeded in control the cell function and fate by changing the local protein activity within cell using the protein encapsulated nanoparticle and focusing light. The positively charged nanoparticles were internalized within cell by means of the cellular uptake mechanism.

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