pH-Sensitive Polymeric Micelles for Enhanced Intracellular Anti-cancer Drug Delivery

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  • Kamimura Masao
    Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba
  • Nagasaki Yukio
    Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba Graduate School of Comprehensive Human Sciences, University of Tsukuba Satellite Laboratory of International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), University of Tsukuba

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Polyion complex (PIC) micelles are expected to be used as nanocarrier for drug delivery. The PIC micelles formed by cationic anti-cancer drug, doxorubicin (DOX) and poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) (PEG-b-PVBP) (DOX@PNP) was prepared with different pH conditions and composition ratio of the mixture. DOX and PEG-b-PVBP were spontaneously self-assembled in aqueous solutions into nanoparticles with average size of 45-55 nm over the entire range of the compositions of the mixtures including stoichiometric electroneutral complexes. The DOX@PNP described here would be promising nanocarrier for anti-cancer drug delivery.

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