Long-term Clinical Evaluation of Intra-arterial Chemoradiotherapy for the Treatment of Carcinomas of the External Auditory Canal and Middle Ear

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  • 外耳道・中耳扁平上皮癌に対する動注化学放射線療法の検討
  • ガイジドウ ・ チュウジ ヘンペイ ジョウヒ ガン ニ タイスル ドウ チュウ カガク ホウシャセン リョウホウ ノ ケントウ

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Abstract

<p>Objectives: We reviewed a study of superselective intra-arterial and systemic chemoradiotherapy for the treatment of advanced and recurrent carcinomas of the external auditory canal and middle ear performed between 2002 and 2009 to evaluate the long-term survival and preservation of organ function after treatment.</p><p>Subjects and Methods: The patients averaged 64.7 years of age, ranging from 49 to 75 years. All patients underwent superselective intra-arterial docetaxel infusion and systemic cisplatin and 5-FU chemotherapy. During and following the chemotherapy, all the patients received radiotherapy at a dose ranging from 30 Gy to 70.2 Gy.</p><p>Results: The follow-up period ranged from 5 to 134 months (median, 60.2 months). No major complications were observed. The fresh three cases with stage IV disease and one case with a local recurrence after surgery, all achieved a CR. One case of residual disease after surgery had PR. One case with a neck recurrence had NC. One case with residual disease after surgery died of pneumonia five months after treatment. One patient died of disease at 15 months after treatment. Four other patients survived for over 47 months.</p><p>Conclusion: We concluded that this therapy is safe and is a useful treatment option for carcinomas of the external auditory canal and middle ear.</p>

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