川崎医科大学耳鼻咽喉科における抗原感作率の検討（第11報）―小児の吸入抗原感作率について―

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  • Incidence of Sensitization to Inhaled Allergens in Children
  • カワサキ イカ ダイガク ジビ インコウカ ニ オケル コウゲン カンサリツ ノ ケントウ(ダイ11ポウ)ショウニ ノ キュウニュウ コウゲン カンサリツ ニ ツイテ

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<p>In recent years, the incidence of allergic diseases has been increasing, and allergic rhinitis is no exception. In particular, an increase in the incidence of Japanese cedar pollinosis and a decrease in the average age of onset have been noted. In the present study, we examined the allergic sensitization rate among children aged 15 years old or younger. The subjects consisted of 279 outpatients of our department who had complained of nasal symptoms and had undergone CAP-radioallergosorbent tests using serum-specific IgE antibodies between 2000 and 2014. The Dermatophagoides farinae sensitization rate was highest, with an incidence of 70.3%, while the Japanese cedar pollen (JCP) sensitization rate was 56.2%. When the sensitization rate was examined according to age group, the JCP sensitization rate was found to increase significantly for older age groups. This study further examined the association between the birth month and JCP sensitization, and a higher positive JCP sensitization rate was observed for children born before pollen dispersal (November to January), compared with children born in other months. Thus, an association between birth month and JCP sensitization was suggested. It has been pointed out that a perennial allergy (such as Dermatophagoides farinae sensitivity) can affect JCP allergy as an enhancing factor. Also, we found a significantly high JCP sensitization rate among children with Dermatophagoides farinae sensitization as well as an increase in duplicate sensitization with age. However, the results also revealed that even at older ages, a certain percentage of children still exhibited sensitization to Dermatophagoides farinae alone and that more children were becoming sensitized to JCP alone. Thus, the presence of a perennial allergy might not always influence JCP sensitization.</p>

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