Optimal overall treatment time in fractionated radiotherapy for head and neck cancers, esophageal cancer, and uterine cervical cancer.

NISHIMURA Yasumasa, OKAJIMA Kaoru, HIRAOKA Masahiro

doi:10.11182/jastro1989.8.303

The efects of overall treatment time (OTT) on local control of radiation therapy (RT) were evaluated to consider optimal OTT in RT. Local control probabilities and acute and late toxicities of esophageal cancer (Stages I-III), glottic laryngeal cancer (Stage I), and uterine cervical cancer (Stage III) treated at Kyoto University Hospital and its affiliated hospitals were analyzed in relation to OTT. For these tumors, local control probabilities decreased when OTT increased. In the multivariate analyses for esophageal cancer and laryngeal cancer, OTT was a significant variable for local control. Only a 1-week interruption of RT due to holidays resulted in a significant reduction of local control probability for T1 glottic tumors. On the other hand, there was no significant difference in local control rates between OTT of 4 weeks and 6 weeks for esophageal cancer. For complications, acute and late toxicities increased when OTT was reduced by accelerated hyperfractionated RT for esophageal cancer. In conclusion, OTT should be kept as short as possible within the limits of tolerance of normal tissues and the patients. We consider that RT must be delivered in the range of 66 to 7OGy in 6 weeks to obtain optimal local control with minimum complications.

Optimal overall treatment time in fractionated radiotherapy for head and neck cancers, esophageal cancer, and uterine cervical cancer.

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