Optimal overall treatment time in fractionated radiotherapy for head and neck cancers, esophageal cancer, and uterine cervical cancer.

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The efects of overall treatment time (OTT) on local control of radiation therapy (RT) were evaluated to consider optimal OTT in RT. Local control probabilities and acute and late toxicities of esophageal cancer (Stages I-III), glottic laryngeal cancer (Stage I), and uterine cervical cancer (Stage III) treated at Kyoto University Hospital and its affiliated hospitals were analyzed in relation to OTT. For these tumors, local control probabilities decreased when OTT increased. In the multivariate analyses for esophageal cancer and laryngeal cancer, OTT was a significant variable for local control. Only a 1-week interruption of RT due to holidays resulted in a significant reduction of local control probability for T1 glottic tumors. On the other hand, there was no significant difference in local control rates between OTT of 4 weeks and 6 weeks for esophageal cancer. For complications, acute and late toxicities increased when OTT was reduced by accelerated hyperfractionated RT for esophageal cancer. In conclusion, OTT should be kept as short as possible within the limits of tolerance of normal tissues and the patients. We consider that RT must be delivered in the range of 66 to 7OGy in 6 weeks to obtain optimal local control with minimum complications.

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詳細情報 詳細情報について

  • CRID
    1390282679308808832
  • NII論文ID
    130003812720
  • DOI
    10.11182/jastro1989.8.303
  • ISSN
    18819885
    10409564
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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